Abstract
The moenomycin trisaccharide degradation product and synthetic disaccharide analogues based on the disaccharide core were bactericidal to gram-positive bacteria, inhibited lipid II polymerization, and inhibited cell wall synthesis in Enterococcus faecalis. Truncating moenomycin to the trisaccharide, and building upon the core disaccharide have both led to molecules possessing properties not shared with their respective parent structures.
MeSH terms
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Aminoglycosides
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Carbohydrate Conformation
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Carbohydrate Sequence
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Disaccharides / chemical synthesis*
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Disaccharides / chemistry
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Disaccharides / pharmacology
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Drug Design
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Gram-Positive Bacteria / drug effects*
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Oligosaccharides / chemical synthesis*
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Oligosaccharides / chemistry
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Oligosaccharides / pharmacology
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Structure-Activity Relationship
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Trisaccharides / chemical synthesis*
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Trisaccharides / chemistry
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Trisaccharides / pharmacology
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Disaccharides
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Oligosaccharides
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Trisaccharides
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moenomycin